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what is A23187:
A23187 is an antibiotic possessing weak in vitro antimicrobial activity against gram positive bacteria and fungi, as well as functioning as a divalent cation ionophore. Ion selectivity is Mn2+>Ca2+=Mg2+>>Sr 2+>Ba2+. Commonly used to increase intracellular Ca2+ levels in intact cells. Also acts as an uncoupler of oxidative phosphorylation and an inhibitor of mitochondrial ATPase activity. A23187 also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin–3 (IL–3) is withdrawn from IL–3–dependent cells. Recommended working concentration is 2–2.5 mM.
A23187 Formula
Formula Weight: 523.6
Molecular Formula: C29H37N3O6
A23187 Usage
For research use only. Not for human or drug use.
Solubility: DMSO, ethyl acetate, and methanol. For
use in aqueous systems, prepare a 100 mM stock solution in anhydrous DMSO.
Microliter amounts of this solution can then be added to H2O with
rapid mixing (e.g. 10 µL into 5 mL of H2O).
Storage and Stability: Refrigerate. Protect from light. Following
reconstitution, aliquot and freeze. This product is stable for 4 years as
supplied.Stock solutions are stable for 2 months frozen.
A23187 references
Pulmonary responses of the guinea pig to inhaled A23187: a brief review
where to buy A23187
AGscientific 5 ug=$50
FERMENTEK |
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